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Adult Onset Deafness Border Collie (Linkage Association Test)

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Test Overview:

Domestic dogs can suffer from hearing losses that can have profound impacts on working ability and quality of life. We have identified a type of adult-onset hearing loss in Border Collies that appears to have a genetic cause, with an earlier age of onset (3–5 years) than typically expected for ageing dogs (8–10 years).

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

USP31

Variant Detected:

c.846+5 T>G

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Complex - Mode Unknown

Research Citation(s):

Yokoyama, 2019, PLoS Genet 8(9): e1002898
2014 Schmutz, S.M. : An analysis of the inheritance pattern of an adult-onset hearing loss in Border Collie dogs. Canine Genet Epidemiol 1:6, 2014. Pubmed reference: 26401323. DOI: 10.1186/2052-6687-1-6.
2012 Yokoyama, J.S., Lam, E.T., Ruhe, A.L., Erdman, C.A., Robertson, K.R., Webb, A.A., Williams, D.C., Chang, M.L., Hytönen, M.K., Lohi, H., Hamilton, S.P., Neff, M.W. : Variation in genes related to cochlear biology is strongly associated with adult-onset deafness in border collies. PLoS Genet 8:e1002898, 2012. Pubmed reference: 23028339. DOI: 10.1371/journal.pgen.1002898.

Associated Breed(s):

Australian Shepherd, Border Collie, Bordoodle, Collie Rough, Collie Smooth,

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