A Locus (Agouti)

Category:

Trait (Associated with Phenotype)

Gene:

ASIP

Variant Detected:

Ay = A>G, Chr24:23393514, T>G, Chr24:23393510; aw/at = 239 bp insertion, Chr24:23365283-23365284; a = C>T, Chr24:23393552

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the ASIP gene will reliably determine if a dog is a carrier for A Locus Agouti.

Research Citation(s):

Dreger DL, Parker HG, Ostrander EA, Schmutz SM. Identification of a mutation that is associated with the saddle tan and black-and-tan phenotypes in Basset Hounds and Pembroke Welsh Corgis. J Hered. 2013 May-Jun; 104(3):399-406. [PubMed: 23519866] Dreger DL, Schmutz SM. A SINE insertion causes the black-and-tan and saddle tan phenotypes in domestic dogs. J Hered. 2011 Sep-Oct; 102 Suppl 1:S11-8. [PubMed: 21846741] Kerns JA, Newton J, Berryere TG, Rubin EM, Cheng JF, Schmutz SM, Barsh GS. Characterization of the dog Agouti gene and a nonagouti mutation in German Shepherd Dogs. Mamm Genome. 2004 Oct; 15(10):798-808. [PubMed: 15520882]

Associated Breed(s):

Affenpinscher, Afghan Hound, Airedale Terrier, Akita , Alaskan Husky, Alaskan Klee Kai, Alaskan Malamute, American Bulldog , American Bully (Micro/Pocket/Classic/XL), American Cocker Spaniel, American Eskimo Dog, American Foxhound, American Hairless (Rat) Terrier, American Pit Bull Terrier, American Staffordshire Terrier, Anatolian Shepherd, Asian Shepherd, Australian Bulldog, Australian Cattle Dog, Australian Cobberdog, Australian Kelpie, Australian Labradoodle , Australian Shepherd, Australian Silky Terrier, Australian Stumpy Tail Cattle Dog, Australian Terrier, Azawakh, Barbet, Basenji, Basset Fauve De Bretagne , Basset Hound, Beagle, Bearded Collie , Beauceron, Bedlington Terrier, Belgian Groenendael Shepherd, Belgian Lakenois Shepherd, Belgian Malinois Shepherd, Belgian Tervueren Shepherd , Bergamasco Shepherd, Bernese Mountain Dog, Bichon Frise, Biewer Terrier, Black Russian Terrier , Bloodhound, Boerboel, Border Collie, Border Terrier, Borzoi, Boston Bulldog, Boston Terrier, Bouvier Des Flandres, Boxer , Boykin Spaniel, Brazilian Terrier, Briard, British Bulldog, Brittany Spaniel , Bull Arab, Bull Terrier, Bulldog, Bullmastiff, Cairn Terrier, Canaan Dog, Cane Corso, Cardigan Welsh Corgi, Catahoula, Catahoula Leopard Dog, Caucasian Shepherd Dog, Cavalier King Charles Spaniel, Cavoodle, Central Asian Shepherd Dog, Cesky Terrier, Chesapeake Bay Retriever , Chihuahua, Chinese Crested, Chinese Shar-Pei, Chinook, Chow Chow, Clumber Spaniel , Cockapoo, Cocker Spaniel, Collie Rough, Collie Smooth, Coonhound, Coton De Tulear, Curly Coated Retriever, Czechoslovakian Vlack, Czechoslovakian Wolfdog, Dachshund , Dachshund Short Hair, Dachshund Standard Long Hair, Dachshund Standard Smooth Hair, Dachshund Standard Wire Hair, Dachshund Wire Hair, Dalmatian, Dandie Dinmont Terrier, Dingo, Dobermann, Dogue de Bordeaux, Drentsche Patrijshond, Drever, Dutch Shepherd, English Cocker Spaniel, English Setter , English Shepherd, English Springer Spaniel, English Toy Spaniel , English Toy Terrier, Eurasier, Field Spaniel, Finnish Hound, Finnish Lapphund, Flat Coated Retriever, Foxhound , French Bulldog, Frisian Water Dog, German Pinscher, German Shepherd Dog, German Shorthaired Pointer, German Spitz , Giant Schnauzer, Golden Retriever, Goldendoodle, Gordon Setter , Great Dane, Great Pyrenees, Greyhound , Griffon Bruxellois - Standard, Groodle, Hamiltonstövare, Hangin' Tree Cowdog, Harlequin Pinscher, Havanese, Havanese Terrier Toy, Hungarian Kuvasz, Hungarian Vizsla, Ibizan Hound, Icelandic Sheepdog, Irish Setter, Irish Terrier, Irish Wolfhound, Italian Greyhound, Italian Spinone, Jack Russell Terrier, Jagd Terrier, Japanese Chin, Japanese Shiba Inu, Japanese Spitz, Kaninchen Dachshund, Karelian Bear Dog, Keeshond, Kerry Blue Terrier, King Charles Spaniel, Komondor, Kooikerhondje, Koolie , Kromfohrländer, Kuvasz, Labradoodle , Labrador Retriever, Lagotto Romagnolo, Lakeland Terrier , Lancashire Heeler, Landseer ECT, Lapponian Herder, Large Munsterlander, Leonberger, Lhasa Apso, Lowchen, Maltese, Manchester Terrier , Maremma Sheepdog, Mastiff , Miki, Miniature American Shepherd, Miniature Australian Shepherd, Miniature Bull Terrier, Miniature Dachshund, Miniature Dachshund Long Hair, Miniature Dachshund Short Hair, Miniature Dachshund Smooth Hair, Miniature Dachshund Wire Hair, Miniature Fox Terrier, Miniature Pinscher , Miniature Poodle, Miniature Schnauzer, Miniature Yorkshire Terrier, Mountain Curr, Mountain Dog , Mudi, Munsterlander, Murray River Retriever, Neapolitan Mastiff, Newfoundland, Norfolk Terrier , Norwegian Elkhound, Norwich Terrier, Nova Scotia Duck Tolling Retriever , Old English Mastiff , Old English Sheepdog , Otterhound, Papillon, Parson Russell Terrier, Patterdale Terrier, Pekingese, Pembroke Welsh Corgi, Peruvian Hairless Dog, Phalene, Plott Hound, Pointer, Polish Lowland Sheepdog, Pomeranian, Portuguese Podengo, Portuguese Water Dog, Prague Ratter, Pug, Puli, Pumi, Pyrenean Sheepdog, Rat Terrier, Rhodesian Ridgeback , Rottweiler , Russian Toy, Saint Bernard , Saluki, Samoyed, Sarplaninac, Schapendoes, Schipperke, Schnoodle, Scotch Collie, Scottish Deerhound, Scottish Terrier , Sealydale Terrier, Sealyham Terrier , Shar Pei, Sheepadoodle, Shetland Sheepdog, Shiba Inu, Shih tzu, Shikoku, Shmoodle, Shoodle, Short Bully, Shortybull, Siberian Husky, Silky Terrier , Skye Terrier, Sloughi, Smithfield, Smooth Fox Terrier, Soft Coated Wheaten Terrier, Spanish Greyhound, Spanish Water Dog, Spoodle, Staffordshire Bull Terrier , Standard Poodle, Standard Schnauzer, Sussex Spaniel, Swedish Lapphund, Swedish Vallhund, Tenterfield Terrier , Thai Ridgeback, Theodore, Tibelier, Tibetan Mastiff, Tibetan Spaniel, Tibetan Terrier , Toy Fox Terrier, Toy Poodle, Treeing Walker Coonhound, Unknown, Volpino Italiano, Water Spaniel , Weimaraner, Welsh Springer Spaniel, West Highland White Terrier , Whippet , White Swiss Shepherd, Wire Fox Terrier, Xoloitzcuintle (Mexican Hairless), Yakutian Laika, Yorkshire Terrier,