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Pheomelanin Colour Intensity CFA21 (Various Breeds)

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Test Overview:

"Pheomelanin Colour Intensity CFA21" appears to refer to a specific classification or genetic marker related to cat fur coloration, particularly its intensity in certain breeds recognized by the Cat Fanciers' Association (CFA). Pheomelanin is a type of melanin pigment responsible for the red, yellow, and amber tones in the fur, hair, and skin of various animals, including cats. Let's break down the important aspects: ### Pheomelanin 1. **Pigment Type**: Pheomelanin is one of two types of melanin found in mammals, the other being eumelanin, which is responsible for black and brown colors. 2. **Color Palette**: Pheomelanin contributes to a range of colors from cream to red and orange. 3. **Genetic Influence**: The expression and intensity of pheomelanin are influenced by genetic factors, including specific alleles that control the production and distribution of this pigment. ### Color Intensity 1. **Genetic Variability**: The intensity of pheomelanin can vary widely, even within a single breed, based on genetic makeup. 2. **Phenotypic Expression**: The visible color can range from pale cream to rich, dark red or orange. 3. **Breeding**: Selective breeding practices can enhance or diminish the intensity of pheomelanin in the fur of cats. ### CFA21 (Cat Fanciers' Association) 1. **Regulation and Standards**: The CFA is an internationally recognized organization that sets breed standards and conducts cat shows to evaluate and uphold these standards. 2. **Genetic Testing**: CFA21 could refer to a specific genetic test or classification within the CFA framework, focusing on the intensity of pheomelanin in various cat breeds. ### Various Breeds Different breeds exhibit varying levels of pheomelanin intensity. Some examples include: 1. **Abyssinian**: Known for a rich, ruddy coloration due to intense pheomelanin. 2. **Somali**: The long-haired counterpart of the Abyssinian, often showcasing strong amber and reddish hues. 3. **Maine Coon**: While primarily noted for their size and sociable nature, they can also exhibit various levels of pheomelanin-driven colors, including cream and red. 4. **Scottish Fold**: This breed can show an array of colors influenced by pheomelanin, from softer creams to more pronounced reds. ### Measurement and Evaluation 1. **Visual Inspection**: Judges often assess the color intensity visually during cat shows, comparing the fur’s hue to the breed standard. 2. **Genetic Testing**: Advances in genetic testing now allow breeders and associations to more accurately understand and predict the color traits inherited by kittens. ### Importance in Breeding and Shows 1. **Standard Conformance**: Adherence to breed standards for color is critical in competitive shows. 2. **Breeding Programs**: Understanding the genetics behind pheomelanin intensity helps breeders produce kittens with desired color traits. ### Conclusion "Pheomelanin Colour Intensity CFA21" seems to encapsulate a focused area of study and classification within the CFA, assessing and understanding the genetic basis and visual expression of red, yellow, and amber fur in various cat breeds. This information is integral to breeding practices, show evaluations, and the maintenance of breed standards.

Category:

Trait (Associated with Phenotype)

Gene:

CFA21

Variant Detected:

The Pheomelanin Colour Intensity CFA21 variant, which is found in various dog breeds, is associated with the intensity of red/yellow pigment in a dog's coat. The term "pheomelanin" refers to the type of melanin that is responsible for red and yellow pigmentation; the other type, eumelanin, accounts for black and brown pigmentation. Key Details: 1. Gene Location: The variant is located on chromosome CFA21 in dogs. Chromosome locations often signify where specific genetic markers or mutations are found that influence certain traits. 2. Function of Variant: This specific variant affects the intensity of pheomelanin. Dogs with certain versions of this variant will have more intense red or yellow pigmentation in their coats compared to others with different versions of this variant. 3. Breeds Affected: The variant is seen in multiple dog breeds. It is not limited to one specific breed, making it a common area of interest for breeders and geneticists who want to understand and predict coat color variations across different breeds.

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

The recommended screening for Pheomelanin Colour Intensity (CFA21) in various breeds refers to genetic testing that helps determine the intensity and shade of red or yellow pigment in a dog's coat. Pheomelanin is responsible for these particular pigmentations in the fur. Here are some key points related to this screening: 1. **Purpose**: The primary purpose of screening for Pheomelanin Colour Intensity is to understand and predict the coat color of offspring in various dog breeds. It helps breeders make informed decisions about mating pairs to achieve desired coat colors in puppies. 2. **Related Gene**: The CFA21 (Canis familiaris autosome 21) chromosome is associated with genes impacting coat color. The specific gene and its variants affecting Pheomelanin intensity can be identified through genetic testing. 3. **Breeds**: This screening can be relevant for numerous breeds where coat color is a significant trait. These can include but are not limited to breeds like: - Dachshunds - Golden Retrievers - Labrador Retrievers - Irish Setters - Vizslas 4. **Genetic Testing**: The test usually involves taking a DNA sample, commonly obtained via a cheek swab or blood sample from the dog. The sample is then analyzed in a laboratory to detect specific genetic markers that influence Pheomelanin intensity. 5. **Result Interpretation**: The results from the test will help determine the genetic make-up of the dog related to the Pheomelanin pigment. This includes whether the dog is likely to produce a lighter or darker shade of red or yellow and whether it carries the potential to produce a range of shades. 6. **Breeding Decisions**: By understanding the genetic predisposition for coat color, breeders can plan pairings that are more likely to result in puppies with desired coat colors, improving predictability in litters. 7. **Health Implications**: While primarily a cosmetic and breeding decision tool, understanding the genetic basis for coat color intensity can sometimes have implications for health. For example, certain coat colors have been associated with higher susceptibility to specific health issues in some breeds. 8. **Ethical Considerations**: Responsible breeding practices should be followed, emphasizing the health and well-being of the dogs over purely aesthetic traits. Genetic diversity and the avoidance of hereditary health issues should be prioritized. In summary, screening for Pheomelanin Colour Intensity CFA21 in various breeds is a genetic test aimed at understanding and predicting red or yellow coat shades in dogs. This information is valuable for breeders seeking to achieve specific coat colors in their breeding programs, but it should be conducted responsibly, considering the overall health and well-being of the animals.

Research Citation(s):

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158882/

Associated Breed(s):

All Breeds (Canine), Mixed Breed,
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