Dermoid Sinus (Ridge Gene)*

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

gene FGF4, FGF3, FGF19, ORAOV1, CCND1

Variant Detected:

Duplication 133 kbp chr18:51398518-51531941

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal Dominant with Incomplete Penetrance

Research Citation(s):

Nat Genet. 2007 Nov;39(11):1318-20. Epub 2007 Sep 30. Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs. Salmon Hillbertz NH1, Isaksson M, Karlsson EK, Hellmén E, Pielberg GR, Savolainen P, Wade CM, von Euler H, Gustafson U, Hedhammar A, Nilsson M, Lindblad-Toh K, Andersson L, Andersson G.