Demyelinating Neuropathy*

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

SBF2

Variant Detected:

G>T

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Granger, N., Feliu-Pascual, A. L., Spicer, C., Ricketts, S., Hitti, R., Forman, O., … Houlden, H. (2019). Charcot-Marie-Tooth type 4B2 demyelinating neuropathy in miniature Schnauzer dogs caused by a novel splicing SBF2 (MTMR13) genetic variant: A new spontaneous clinical model. PeerJ, 2019(11