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Congenital Muscular Dystrophy (Italian Greyhound Type)

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Test Overview:

Congenital Muscular Dystrophy (CMD), identified in Italian Greyhounds, is an autosomal recessive disorder. This means a dog must inherit two copies of the specific genetic variant to be at high risk for developing CMD. A carrier dog, possessing just one copy of the variant, can be responsibly bred with a dog that has no copies of the CMD variant. Such pairings typically result in about half the puppies being carriers and the other half being clear of the variant. It is crucial to test puppies from litters that might carry the variant before they are bred. Breeding two carrier dogs is strongly discouraged as this increases the likelihood of producing puppies that are affected by CMD. It's also important to note that symptoms similar to those associated with this CMD variant might arise from other genetic or clinical causes, underscoring the necessity of comprehensive genetic testing. For guidance on breeding and testing strategies, visit Orivet’s dedicated resources or contact our genetic specialists.

Category:

Musculoskeletal - Associated with muscles, bones and associated structures

Gene:

LAMA2

Variant Detected:

nonsense c.3285G>A/p.(W1095*) chr1

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

https://pubmed.ncbi.nlm.nih.gov/34828429/

Associated Breed(s):

Italian Greyhound,

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